Nfl Week 4 Predictions Straight Up 2025 Predictions.  — three weeks into the 2025 nfl season, it seems as though the underdogs won't stop barking when it comes to spreads of six points or more.  — 2025 nfl week 4:

 — with week 4 of the nfl season upon us, we’ve harnessed our dynamic predictive analytics model to deliver nfl straight up picks for all 16 games this week.  — the sports illustrated team breaks down their picks to win all 16 games in week 4 of the 2025 nfl season.